Diclofenac
NSAIDAlso known as: Diclofenac sodium · Voltaren
An NSAID used for muscle and joint pain and inflammation, available as slow-release tablets and topical formulations.
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Acute pain (sprains, strains)
- Dysmenorrhoea
- Post-operative pain
- Voltaren (originator brand)
- Various locally registered generic brands (diclofenac sodium/potassium; prescription required)
- 25mg / 50mg (enteric-coated tablet)
- 75mg / 100mg (SR tablet)
- 12.5mg / 25mg / 50mg (suppository)
- Topical gel/cream
What is Diclofenac used for?
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation, pain and fever by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes and lowering prostaglandin production. It is commonly used for arthritis, musculoskeletal pain and menstrual pain. Voltaren is one of the best-known diclofenac brand names.
How to take Diclofenac and adjust the dose
A typical adult oral dose is 75-150mg daily in 2-3 divided doses; up to 200mg/day may be used for period pain. SR tablets are usually 100mg once daily. Take with or after food to reduce GI irritation. Use the lowest effective dose for the shortest time needed to control symptoms. Topical products are applied to the affected area several times daily per the product label. (General reference range only — follow your doctor's prescription and the package insert; ask a pharmacist if unsure.)
Diclofenac side effects
- Common: stomach pain, indigestion, nausea, headache, dizziness
- Serious (rare but important): GI bleeding/ulceration/perforation, increased risk of heart attack or stroke, liver/kidney impairment, severe allergic/skin reactions
Who should not take Diclofenac?
- Contraindicated in those allergic to diclofenac or other NSAIDs
- Contraindicated with active peptic ulcer or GI bleeding history
- Contraindicated/used with caution in severe heart failure, ischaemic heart disease, cerebrovascular disease
- Contraindicated in severe hepatic or renal impairment
- Contraindicated in late pregnancy; consult doctor in early pregnancy and breastfeeding
- Contraindicated after recent CABG surgery
This page is general reference information only, not medical advice. Always confirm dosage, interactions, and whether this medicine is suitable for you with a pharmacist or doctor before use.
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