Pregabalin

What is Pregabalin used for?

Pregabalin (brand name Lyrica) is an anticonvulsant/neuropathic pain medication that works by modulating calcium channel activity in the central nervous system, reducing excessive nerve signalling. It is used to relieve neuropathic pain (e.g. diabetic neuropathy, post-herpetic neuralgia), as adjunctive therapy for partial-onset seizures, and to treat generalized anxiety disorder.

How to take Pregabalin and adjust the dose

Adults typically start at a low dose — around 150mg/day (in 2 divided doses, i.e. 75mg twice daily) — which may be increased after about a week to 300mg/day based on response and tolerability, and further increased if needed up to a maximum of 600mg/day (in 2-3 divided doses). Not all patients require the maximum dose. Dose must be adjusted for renal impairment. Do not stop abruptly — discontinuation should be gradual under medical guidance. May be taken with or without food. (Confidence: moderate-high — general dose range based on NHS and international prescribing information; exact HK prescribing details should be confirmed against the doctor's prescription and product label)

Pregabalin side effects

• Common: drowsiness, dizziness, fatigue, headache, tremor
• Less common: blurred vision, indigestion, weight gain, leg swelling, memory problems, mood changes, euphoria
• Rare but important: hallucinations, rash, dependence/addiction risk, angioedema (allergic reaction)

Who should not take Pregabalin?

• Contraindicated in known hypersensitivity to pregabalin
• Use with caution and monitoring in patients with history of substance abuse/addiction
• Dose adjustment required in renal impairment
• Consult a doctor if pregnant or breastfeeding
• Avoid alcohol during treatment as it enhances sedative effect
• Combining with other CNS depressants (opioids, benzodiazepines) increases respiratory depression risk
• Do not stop abruptly